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32 The clinical importance of this conversation is unclear right now. While knowledge will not be obtainable, the same response may perhaps occur with voriconazole. Both equally fluconazole and voriconazole are inhibitors of CYP3A4, the hepatic microsomal isoenzyme chargeable for metabolism of testosterone.[33]
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Androgens Use a high lipid solubility, which allows them to achieve goal tissue cells promptly. When testosterone enters cells, it is enzymatically converted to five-alpha-dihydrotestosterone and joins with cystolic receptors to produce a loosely bound intricate. The steroid-receptor intricate triggers mobile alterations while in the nucleus and the beginning of transcription, that are the results in of androgen action.
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